HALF A MILLION DOWNLOADS REACHED - Helping Safeguard children from psychiatric drug harm due to possible severe toxic side effects. We need alternatives like psychological interventions, physical activity, or mindfulness training as a first course of action. Let's 'Enable not Label' kids to give them better futures - - - - - - - - -"There can be no keener examination of a society's soul than the way it chooses to treat its children." - - - - -
- Nelson Mandela
Clinical Trials Medical Group, Glendale, CA 91206, USA.
objective of this study was to explore the efficacy of combination therapy with
citalopram plus omega-3 fatty acids versus citalopram plus placebo (olive oil)
in the initial treatment of individuals with major depressive disorder (MDD).
We hypothesized that combination therapy would lead not only to greater
efficacy but also to a more rapid onset of therapeutic response.
subjects participated in this 9-week randomized, masked, placebo-controlled
study of combination therapy (two 1 g capsules containing a blend of 900 mg of
eicosapentaenoic acid, 200 mg of and docosahexaenoic acid, and 100 mg of other
omega-3 fatty acids twice daily plus citalopram) versus monotherapy (two 1 g
capsules of olive oil per day plus citalopram) treatment of MDD.
combination therapy demonstrated significantly greater improvement in Hamilton
Depression Rating scale scores over time (F = 7.32; df 1,177; P = 0.008)
beginning at week 4 (t = -2.48; df 177; P = 0.014).
therapy was more effective than monotherapy in decreasing signs and symptoms of
MDD during the 8 weeks of active treatment; however, combination therapy did
not seem to enhance the speed of the initial antidepressant response. These
findings suggest that there may be an advantage to combining omega-3 fatty
acids with a selective serotonin uptake inhibitor in the initial treatment of
individuals with MDD. A larger definitive study is warranted.