BRITISH JOURNAL OF P SYCHIATRY(2 0 0 6) 1 8 8 ,p 1 2 2 to p 1 2 7.
Schizophrenia, neuroleptic medication
MATTI JOUKAMAA, MARKKU HELIOVAARA, PAUL KNEKT,
HELIO« VAARA, ARPO AROMAA, RAIMO RAITASALO and VILLE LEHTINEN
There is an excess of
death from natural causes among people
Schizophrenia and its treatment
with neuroleptics were studied for their
prediction of mortality in a representative
population sample of 7217 Finns aged 5 to 30
A comprehensive health
examination was carried out at baseline.
Schizophrenia was determined using the
Present State Examination and previous
During a17-year follow-up, 39
of the 99 people with schizophrenia died.
Adjusted for age and gender, the relative
mortality risk between those with schizophrenia
and others was 2.84 (95% CI
after further adjusting for somatic
massindex, smoking, exercise, alcohol
intakeandeducation.The number of neuroleptics
used at the time of the baseline
survey showed a graded relation to
mortality.Adjusted for age, gender,
somatic diseases and other potential risk
factors for premature death, the relative
riskwas 2.50 (95% CI1.46^4.30) per
There is an urgent need to
ascertain whether the high mortality in
schizophrenia is attributable to the disorder
itself or the antipsychotic medication.